Hepatotoxicity of External Radiotherapy for Hepatocellular Carcinoma in the Setting of Prior Yttrium-90 Radioembolization

EBRT following Y-90 was not associated with increased hepatotoxicity or inferior oncologic outcomes compared with EBRT alone. When delivered with individualized planning, including fractionation, EBRT represents a safe and effective salvage modality for patients with residual or recurrent HCC after Y-90.

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Publication Details

Journal
American Journal of Clinical Oncology
Published
2026-02-05
DOI
https://doi.org/10.1097/coc.0000000000001300
Primary Topic
Hepatocellular Carcinoma Treatment and Prognosis
Type
article
Field-Weighted Citation Impact
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article

Hepatotoxicity of External Radiotherapy for Hepatocellular Carcinoma in the Setting of Prior Yttrium-90 Radioembolization

Bailey Nelson, Ismael Assi, Darren Lee, Sarah Feldkamp et al.
American Journal of Clinical Oncology
Hepatocellular Carcinoma Treatment and Prognosis
article

Hepatotoxicity of External Radiotherapy for Hepatocellular Carcinoma in the Setting of Prior Yttrium-90 Radioembolization

Bailey Nelson, Ismael Assi, Darren Lee, Sarah Feldkamp, Claire Niewiara, Nedas Semaska, Bashar Nahab, Kyle Wang
article en

Abstract

EBRT following Y-90 was not associated with increased hepatotoxicity or inferior oncologic outcomes compared with EBRT alone. When delivered with individualized planning, including fractionation, EBRT represents a safe and effective salvage modality for patients with residual or recurrent HCC after Y-90.

American Journal of Clinical Oncology
Advocate Lutheran General Hospital (US), Radiation Oncology Associates (US), University of Cincinnati (US), University of Cincinnati Medical Center (US)
Good health and well-being
Openalex Percentile: Top 59%
Hepatocellular Carcinoma Treatment and Prognosis
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