Vaping Δ <sup>9</sup> -tetrahydrocannabinol (Δ <sup>9</sup> -THC) in liquid forms: pharmacokinetics, pharmacodynamics, and regulatory implications

While more potent than smoked cannabis, vaped liquid formulations with Δ<sup>9</sup>-THC may have a similar PK/PD profile through modulation of Δ<sup>9</sup>-THC delivery by consumer use behaviors. Potential health effects of high-potency vaping products with Δ<sup>9</sup>-THC in liquid form need to be carefully studied. Lastly, researchers should continue to think creatively about how this important work can progress, while restrictions on Δ<sup>9</sup>-THC continue to hinder research.

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Publication Details

Journal
Expert Review of Clinical Pharmacology
Published
2026-02-01
DOI
https://doi.org/10.1080/17512433.2026.2630756
Primary Topic
Cannabis and Cannabinoid Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Vaping Δ 9 -tetrahydrocannabinol (Δ 9 -THC) in liquid forms: pharmacokinetics, pharmacodynamics, and regulatory implications

Danielle M. Smith, Block Aw, Maciej Lukasz Goniewicz
Expert Review of Clinical Pharmacology
Cannabis and Cannabinoid Research
article

Vaping Δ 9 -tetrahydrocannabinol (Δ 9 -THC) in liquid forms: pharmacokinetics, pharmacodynamics, and regulatory implications

Danielle M. Smith, Block Aw, Maciej Lukasz Goniewicz
article en

Abstract

While more potent than smoked cannabis, vaped liquid formulations with Δ<sup>9</sup>-THC may have a similar PK/PD profile through modulation of Δ<sup>9</sup>-THC delivery by consumer use behaviors. Potential health effects of high-potency vaping products with Δ<sup>9</sup>-THC in liquid form need to be carefully studied. Lastly, researchers should continue to think creatively about how this important work can progress, while restrictions on Δ<sup>9</sup>-THC continue to hinder research.

Expert Review of Clinical PharmacologyVol. 19(2)
Roswell Park Comprehensive Cancer Center (US)
Openalex Percentile: Top 59%
Cannabis and Cannabinoid Research
DOISourceOpenAlex
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Vaping Δ <sup>9</sup> -tetrahydrocannabinol (Δ <sup>9</sup> -THC) in liquid forms: pharmacokinetics, pharmacodynamics, and regulatory implications — Danielle M. Smith, Block Aw, et al. · Expert Review of Clinical Pharmacology (2026) | TGRS Research Map | TGRS