Association of <i>CYP2C19</i> Single Nucleotide Polymorphism With Hemorrhagic Cystitis After Pediatric Allogeneic Hematopoietic Stem Cell Transplantation
This study demonstrates that CYP2C19 (c.681G > A) GA/AA genotype, older age, and peri-ES are each independent risk factors for HC after allo-HSCT. These findings highlight the value of pharmacogenetic and clinical profiling in predicting susceptibility to HC and guiding personalized preventive strategies, contributing to a deeper understanding of the interplay among genetic predisposition, immune responses, and chemotherapy-related toxicity in HC pathogenesis.
Authors
- Xinni Bian
- Shuiyan Wu
- Shaoyan Hu
- J Ling (ORCID: https://orcid.org/0009-0007-9859-129X)
- H H Zhang
- Bohan Li (ORCID: https://orcid.org/0000-0003-2952-146X)
- Wen Zhang (ORCID: https://orcid.org/0000-0001-5166-0736)
- Liyan Fan
- Y. Hu
- Zhizhuo Du
- Jiayue Qin
- Conglian Qiu
- Yongping Zhang
- Jie Li
- Qingwei Wang
- Li Gao
- Xin Liu
- Qi Ji
- Peifang Xiao
- Jun Lu
- Lixia Liu
Institutions
- Soochow University (CN)
- Beijing VDJBio (China) (CN)
- Children's Hospital of Suzhou University (CN)
Publication Details
- Journal
- Clinical Transplantation
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1111/ctr.70474
- Primary Topic
- Polyomavirus and related diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Soochow University