Integrative Computational and Transcriptional Analysis of NF-κB and HIF-1α Modulation Following Doxorubicin Treatment in Triple-Negative Breast Cancer Cells
This study provides transcriptional-level evidence suggesting the involvement of NF-κB- and HIF-1α-related pathways in the cellular response of TNBC cells to doxorubicin treatment. By integrating computational predictions with early experimental validation, the findings generate biologically plausible hypotheses for further mechanistic and functional investigations, contributing to foundational cancer research efforts aligned with SDG 3 (Good Health and Well-Being).
Authors
- Hermin Aminah Usman (ORCID: https://orcid.org/0000-0003-2167-2669)
- Astrid Feinisa Khairani (ORCID: https://orcid.org/0000-0001-7242-4791)
- Muhammad Hasan Bashari (ORCID: https://orcid.org/0000-0001-7298-0317)
- Raden Azhar
- Arif Setiawansyah
- Nurul Utami
Institutions
- Lampung University (ID)
- Dr. Hasan Sadikin General Hospital (ID)
- Politeknik Medica Farma Husada Mataram (ID)
- Universitas Bandar Lampung (ID)
- Padjadjaran University (ID)
Publication Details
- Journal
- Journal of Experimental Pharmacology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.2147/jep.s576572
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministrstvo za visoko šolstvo, znanost in tehnologijo
- Lembaga Pengelola Dana Pendidikan
- Universitas Padjadjaran