Vascular Comorbidities and an Increased Comorbidity Score Are Associated With Disability and Disability Progression in Secondary Progressive Multiple Sclerosis
VCM and also increased comorbidity burden per se are associated with increased disability. Disability worsening over 96 weeks was most evident in those with hyperlipidaemia and increased comorbidity burden.
Authors
- Nevin John (ORCID: https://orcid.org/0000-0002-9834-4498)
- Yingtong Li (ORCID: https://orcid.org/0000-0002-0691-0262)
- Floriana De Angelis (ORCID: https://orcid.org/0000-0002-9833-1435)
- Ferrán Prados (ORCID: https://orcid.org/0000-0002-7872-0142)
- Alberto Calvi (ORCID: https://orcid.org/0000-0002-1953-2803)
- J. Chataway
- Jon Stutters
- Thanh Phan
- Thomas Williams
- Anisha Doshi
- for the MS‐SMART Investigators
- Domenico Plantone
Institutions
- University of Siena (IT)
- Universitat Oberta de Catalunya (ES)
- Queen Mary University of London (GB)
- National Institute for Health and Care Research (GB)
- Monash Health (AU)
- UCL Biomedical Research Centre (GB)
- Fundació Clínic per a la Recerca Biomèdica (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- University College London (GB)
- Monash University (AU)
Publication Details
- Journal
- European Journal of Neurology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1111/ene.70517
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Multiple Sclerosis Society
- Sanofi
- Queen Mary University of London
- NHS Greater Glasgow and Clyde
- University Hospitals Plymouth NHS Trust
- National Institute for Health and Care Research
- Multiple Sclerosis Society
- University of Warwick
- Imperial College London
- Imperial College Healthcare NHS Trust
- University College London
- University of Oxford
- University of Leeds
- University of Nottingham
- University of Sussex
- University of Edinburgh
- Oxford University Hospitals NHS Foundation Trust
- University College London Hospitals NHS Foundation Trust
- Sheffield Teaching Hospitals NHS Foundation Trust
- Barts Health NHS Trust
- Medical Research Council
- Efficacy and Mechanism Evaluation Programme
- Warwick Medical School