Predictive Value of Plasma P-tau217 and <i>APOE</i> Genotype for Preclinical Cognitive Decline in Alzheimer’s Disease
Plasma P-tau217 levels and the presence <i>APOE</i> genotype can be used to estimate the interval before the onset of overt cognitive impairment and the diagnosis of AD. The findings here support the use of commercially available <i>APOE</i> genotyping and plasma P-tau217 to determine optimal timing for therapeutic intervention, particularly during the preclinical phase of the disease.
Authors
- Martin Medrano (ORCID: https://orcid.org/0000-0003-3673-9088)
- Diones Rivera Mejía (ORCID: https://orcid.org/0000-0001-5935-8005)
- Yuexuan Xu (ORCID: https://orcid.org/0000-0002-2732-7199)
- Tamil Iniyan Gunasekaran (ORCID: https://orcid.org/0000-0002-8639-5060)
- Danurys Sanchez (ORCID: https://orcid.org/0000-0001-8273-0952)
- Angel Piriz
- Rafael Lantigua (ORCID: https://orcid.org/0000-0003-4854-7331)
- Ramiro Eduardo Rea Reyes (ORCID: https://orcid.org/0000-0001-9749-282X)
- Matthew J. Maenner (ORCID: https://orcid.org/0000-0003-4750-5607)
- Adam Brickman
- Sanjay Asthana
- Sid O'Bryant
- Richard Mayeux
- Jennifer J Manly
- Lawrence Honig
- Badri N Vardarajan
- Yian Y Gu
- David A Bennett
- Sterling C. Johnson
- Melissa Petersen
- Rachael Wilson
Institutions
- University of North Texas (US)
- Rush University Medical Center (US)
- NewYork–Presbyterian Hospital (US)
- University of Wisconsin–Madison (US)
- Pontificia Universidad Católica Madre y Maestra (DO)
- University of North Texas Health Science Center (US)
- New York Hospital Queens (US)
- Instituto Tecnológico de Santo Domingo (DO)
- Universidad Nacional Pedro Henríquez Ureña (DO)
- Columbia University (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-09
- DOI
- https://doi.org/10.64898/2026.02.06.26345774
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Disease Neuroimaging Initiative
- National Institutes of Health
- National Institute on Aging
- National Center for Advancing Translational Sciences
- National Institute on Minority Health and Health Disparities