Causal relationship between renin-angiotensin system inhibitors and cancer: a two-sample, two-step Mendelian randomization study
This MR study provides robust genetic evidence supporting a causal protective role of ACEI/ARB use in reducing the risk of gastric, colorectal, lung, breast, and endometrial cancers, which is partially mediated by VEGF-A, total cholesterol, triglycerides, LDL-C, and HDL-C.
Authors
- Chenggong Zeng (ORCID: https://orcid.org/0000-0002-2224-6031)
- Yan Mao
- Juanhua Zhu
- Zijun Zhen
- Xi Zhen
- Zhiqing Wei
Institutions
- Pennsylvania State University (US)
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Penn State Milton S. Hershey Medical Center (US)
Publication Details
- Journal
- Chinese Clinical Oncology
- Published
- 2026-02-01
- DOI
- https://doi.org/10.21037/cco-2025-aw-131
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00