Lysine demethylase 1A alleviates Alzheimer disease progression by regulating the leucine carboxyl methyltransferase 1/protein phosphatase 2 catalytic subunit alpha/transcription factor EB pathway via O‐GlcNAcase‐mediated forkhead box transcription fa

Overall, LSD1 restrained neuronal ferroptosis to alleviate the progression of AD by regulating LCMT1/PP2A/TFEB pathway via OGA-mediated FOXA2 O-GlcNAcylation modification, providing novel mechanistic insights into the deeper understanding of AD pathogenesis and the development of potential drug targets.