Assessment of mosaic loss of chromosome Y in pulmonary fibrosis reveals limited association with susceptibility or disease severity
Our study confirms the existence of mLOY in PF patients, suggests that mLOY is not a major driver of IPF, and might support a triangulation model where telomere shortening leads to both IPF and mLOY.
Authors
- Jonathan A. Kropski (ORCID: https://orcid.org/0000-0002-8923-1344)
- I M Stewart
- Samuel Moss (ORCID: https://orcid.org/0000-0002-1872-9110)
- Paul J. Wolters (ORCID: https://orcid.org/0000-0002-3108-6164)
- Philip L. Molyneaux (ORCID: https://orcid.org/0000-0003-1301-8800)
- Dapeng Wang (ORCID: https://orcid.org/0000-0002-9925-4574)
- John R. B. Perry
- Toby M. Maher
- Simon R Johnson
- Niran Hadad
- Yajie Zhao
- R Gisli Jenkins
- Nicholas E Banovich
- Elena Lopez-Jimenez
Institutions
- University of Southern California (US)
- Translational Genomics Research Institute (US)
- University of Nottingham (GB)
- University of California, San Francisco (US)
- Vanderbilt University (US)
- University of Cambridge (GB)
- Wellcome/MRC Institute of Metabolic Science (GB)
- Nottingham Biomedical Research Centre (GB)
- MRC Epidemiology Unit (GB)
- China University of Petroleum, East China (CN)
- Imperial College London (GB)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- BMJ Open Respiratory Research
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1136/bmjresp-2025-003846
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Cancer Research UK
- National Institute for Health and Care Research
- Department of Health and Social Care
- Medical Research Council