Randomized Controlled Trials and Real‐World Evidence in Allergen Immunotherapy: A Critical Reflection on Methodological Paradigms, Ethical Implications, and Industry Influence
Neither RCTs nor RWE, taken in isolation, provide a sufficient picture of the efficacy and safety of AIT. Only an integrated approach, combining methodological rigor and pragmatic relevance, accompanied by independent monitoring of conflicts of interest and greater transparency, can support truly evidence-based medicine.
Authors
- Marcello Melluso
- A. Seidita
- Gabriele Di Lorenzo (ORCID: https://orcid.org/0000-0002-0197-5665)
Institutions
- Department of Health (ES)
- Institute for Biomedical Research and Innovation (IT)
- University of Palermo (AR)
- University of Palermo (IT)
Publication Details
- Journal
- Journal of Evaluation in Clinical Practice
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1111/jep.70382
- Primary Topic
- Allergic Rhinitis and Sensitization
- Type
- article
- Field-Weighted Citation Impact
- 0.00