Impact of center‐to‐center distance and slit width on robust target coverage and PVDR for proton minibeam radiation therapy using a commercial TPS

This study demonstrates that robust single-beam pMBRT planning in RayStation is feasible but can be limited by a trade-off between PVDR and robust target coverage, and heavily dependent on beam depth and geometry. These findings provide insights into the effects of beam geometry and collimator parameters on PVDR and robustness, guiding future investigations on robust pMBRT planning.

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Publication Details

Journal
Medical Physics
Published
2026-02-01
DOI
https://doi.org/10.1002/mp.70340
Primary Topic
Radiation Therapy and Dosimetry
Type
article
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article

Impact of center‐to‐center distance and slit width on robust target coverage and PVDR for proton minibeam radiation therapy using a commercial TPS

Kelvin Ng Wei Siang, Mischa S. Hoogeman, Erik Tranéus, Anna C. Prins
Medical Physics
Radiation Therapy and Dosimetry
article

Impact of center‐to‐center distance and slit width on robust target coverage and PVDR for proton minibeam radiation therapy using a commercial TPS

Kelvin Ng Wei Siang, Mischa S. Hoogeman, Erik Tranéus, Anna C. Prins
article en

Abstract

This study demonstrates that robust single-beam pMBRT planning in RayStation is feasible but can be limited by a trade-off between PVDR and robust target coverage, and heavily dependent on beam depth and geometry. These findings provide insights into the effects of beam geometry and collimator parameters on PVDR and robustness, guiding future investigations on robust pMBRT planning.

Medical PhysicsVol. 53(2)
Proton Therapy Centre (CZ), Erasmus MC Cancer Institute (NL), RaySearch Laboratories (Sweden) (SE)
Openalex Percentile: Top 63%
Radiation Therapy and Dosimetry
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