Development of enzyme-linked immunosorbent assays for the detection of myositis-specific autoantibodies against signal recognition particle, nuclear matrix protein 2, and small ubiquitin-like modifier activating enzyme

The newly developed ELISA systems showed excellent agreement with IP assays, supporting their applicability for routine clinical use in detecting anti-SRP, anti-NXP2, and anti-SAE autoantibodies.

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Publication Details

Journal
Modern Rheumatology
Published
2026-02-09
DOI
https://doi.org/10.1093/mr/roag003
Primary Topic
Inflammatory Myopathies and Dermatomyositis
Type
article
Field-Weighted Citation Impact
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article

Development of enzyme-linked immunosorbent assays for the detection of myositis-specific autoantibodies against signal recognition particle, nuclear matrix protein 2, and small ubiquitin-like modifier activating enzyme

S. Sato, Hiroki Abe, Akihiro Murakami, Yukihiro Nishikawa et al.
Modern Rheumatology
Inflammatory Myopathies and Dermatomyositis
article

Development of enzyme-linked immunosorbent assays for the detection of myositis-specific autoantibodies against signal recognition particle, nuclear matrix protein 2, and small ubiquitin-like modifier activating enzyme

S. Sato, Hiroki Abe, Akihiro Murakami, Yukihiro Nishikawa, Ran Nakashima, Shun Matsuzawa, Takuya Isayama, Masataka Kuwana, Manabu Fujimoto, Naoko Okiyama, Shunsuke Kidani, Ichizo Nishino, Tetsuya Kikuchi
article en

Abstract

The newly developed ELISA systems showed excellent agreement with IP assays, supporting their applicability for routine clinical use in detecting anti-SRP, anti-NXP2, and anti-SAE autoantibodies.

Modern Rheumatology
Tokyo Medical and Dental University (JP), Tokai University (JP), Kyoto University (JP), Osaka City University (JP), National Center of Neurology and Psychiatry (JP), Medical & Biological Laboratories (Japan) (JP), Nippon Medical School Hospital (JP), Nippon Medical School (JP), The University of Osaka (JP)
Openalex Percentile: Top 60%
Inflammatory Myopathies and Dermatomyositis
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Development of enzyme-linked immunosorbent assays for the detection of myositis-specific autoantibodies against signal recognition particle, nuclear matrix protein 2, and small ubiquitin-like modifier activating enzyme — S. Sato, Hiroki Abe, et al. · Modern Rheumatology (2026) | TGRS Research Map | TGRS