A Tale of Monozygotic Twins With Down Syndrome: Divergent Clinical Paths to Dementia
Discordant cognitive decline could not be explained by clinical co-morbidities, medications, or environment, suggesting that other factors, such as epigenetics, could underlie phenotypic variability and variable risk for AD in DS and deserves further study.
Authors
- Giovi G. Hersch
- Florence Lai (ORCID: https://orcid.org/0000-0003-4354-0624)
- Christy L. Hom
- Gianna Eloise Acosta
- Gabriella Leka
- Joseph H. Lee
- Margaret B. Pulsifer
- Laura Xicota
Institutions
- Harvard University (US)
- University of California, Irvine (US)
- Columbia University Irving Medical Center (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Neurology Open Access
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1212/wn9.0000000000000058
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health