7,8-Dihydroxyflavone alleviates ulcerative colitis by binding keap1 to activate an slc7a11-dependent inhibition of NF-κB p65 signaling in macrophages

Our study underscores the potential therapeutic application of 7,8-DHF in managing inflammatory conditions, particularly ulcerative colitis.

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Publication Details

Journal
Journal of Advanced Research
Published
2026-02-01
DOI
https://doi.org/10.1016/j.jare.2026.01.078
Primary Topic
NF-κB Signaling Pathways
Type
article
Field-Weighted Citation Impact
0.00
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article

7,8-Dihydroxyflavone alleviates ulcerative colitis by binding keap1 to activate an slc7a11-dependent inhibition of NF-κB p65 signaling in macrophages

Xue-Wei Luo, HE Xian-jin, Zhongsheng Li, Dan Du et al.
Journal of Advanced Research
NF-κB Signaling Pathways
article

7,8-Dihydroxyflavone alleviates ulcerative colitis by binding keap1 to activate an slc7a11-dependent inhibition of NF-κB p65 signaling in macrophages

Xue-Wei Luo, HE Xian-jin, Zhongsheng Li, Dan Du, Zhen Jin, Zi-Dan Zhou, Qi Wang, Zhe George Zhang, Wei (Vivian) Wang, Guang-Yu Zhang, Xiao-Bao Deng, Xiao Renshaw Wang, You-Zhi Tang, Chen Yang
article en

Abstract

Our study underscores the potential therapeutic application of 7,8-DHF in managing inflammatory conditions, particularly ulcerative colitis.

Journal of Advanced Research
South China Agricultural University (CN), Sun Yat-sen University (CN), Xiamen University (CN), First Affiliated Hospital of Xiamen University (CN), Key Laboratory of Guangdong Province (CN), Zhongshan Hospital of Xiamen University (CN), South China University of Technology (CN)
Good health and well-being
Openalex Percentile: Top 62%
NF-κB Signaling Pathways
DOIOpen Access PDFOpenAlex
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7,8-Dihydroxyflavone alleviates ulcerative colitis by binding keap1 to activate an slc7a11-dependent inhibition of NF-κB p65 signaling in macrophages — Xue-Wei Luo, HE Xian-jin, et al. · Journal of Advanced Research (2026) | TGRS Research Map | TGRS