Perinatal and early infant outcomes after first‐versus second‐generation integrase strand transfer inhibitor use in pregnancy

There were no significant associations between second-generation INSTIs and adverse perinatal outcomes compared to first-generation INSTIs. These findings support the ongoing use of second-generation INSTIs in pregnancy with continued careful surveillance of perinatal outcomes.

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Publication Details

Journal
HIV Medicine
Published
2026-02-10
DOI
https://doi.org/10.1111/hiv.70206
Primary Topic
HIV/AIDS drug development and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Perinatal and early infant outcomes after first‐versus second‐generation integrase strand transfer inhibitor use in pregnancy

Laura Sauvé, Isabelle Boucoiran, Ari Bitnun, Alena Tse‐Chang et al.
HIV Medicine
HIV/AIDS drug development and treatment
article

Perinatal and early infant outcomes after first‐versus second‐generation integrase strand transfer inhibitor use in pregnancy

Laura Sauvé, Isabelle Boucoiran, Ari Bitnun, Alena Tse‐Chang, Rosa Balleny, Jeannette L. Comeau, J Wong, Fatima Kakkar, Deborah Money, Terry Lee, Jason Brophy, Joel Singer
article en

Abstract

There were no significant associations between second-generation INSTIs and adverse perinatal outcomes compared to first-generation INSTIs. These findings support the ongoing use of second-generation INSTIs in pregnancy with continued careful surveillance of perinatal outcomes.

HIV Medicine
Dalhousie University (CA), University of British Columbia (CA), University of Ottawa (CA), University of Alberta (CA), University of Toronto (CA), University of Saskatchewan (CA), Centre for Advancing Health Outcomes (CA), HIV Legal Network (CA), Université de Montréal (CA)
Good health and well-being
Openalex Percentile: Top 60%
HIV/AIDS drug development and treatment
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