Podocyte-derived endothelin-1 and endothelial cell endothelin A receptors are essential for glomerular injury in mouse models of focal segmental glomerulosclerosis
Our studies provide in vivo evidence that crosstalk of podocyte-derived ET1 with activation of GEC ET<sub>A</sub> contributes to glomerular injury in FSGS.
Authors
- Kristin Meliambro
- W. Zhang
- Jonathan C. Haydak (ORCID: https://orcid.org/0000-0002-9091-8987)
- Sean Lefferts
- Ubong S. Ekperikpe (ORCID: https://orcid.org/0000-0002-9962-5371)
- Hunter W. Korsmo (ORCID: https://orcid.org/0000-0002-5612-1528)
- Abhijit Naik
- Zhengzi Yi (ORCID: https://orcid.org/0009-0002-6741-0736)
- Kirk N. Campbell (ORCID: https://orcid.org/0000-0003-3855-8651)
- Donald E. Kohan (ORCID: https://orcid.org/0000-0002-3981-2941)
- Ilse S Daehn
- Edgar A. Otto
- Serena Zhao
- Liping Yu
- Börje Haraldsson
- Phillip J. McCown
- Evren U. Azeloglu
Institutions
- University of Utah (US)
- University of Michigan (US)
- Michigan Center for Translational Pathology (US)
- University of Gothenburg (SE)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Kidney International
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1016/j.kint.2026.01.014
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- University of Tsukuba
- National Institutes of Health
- Congressionally Directed Medical Research Programs