Hypoxia-preconditioned mesenchymal stromal cell–derived exosomes attenuate LPS-induced acute lung injury and early epithelial remodeling in mice: evidence for a miR-486a-5p–Skp2–GATA4 axis
Hypoxia-preconditioned bone marrow-derived mesenchymal stromal cell (BMSC) exosomes demonstrate significant potential to alleviate LPS-induced acute injury and early epithelial remodeling by engaging a miR-486a-5p/Skp2/GATA4 working model, offering a proof-of-concept therapeutic strategy for ALI.
Authors
- Rifeng Liu
- Yanlin Wu (ORCID: https://orcid.org/0000-0002-1372-1822)
- Jun Lin
- Qun Lin
- Lihua Lei
- Siling Zou
- Can Lin
Institutions
- Fujian Medical University (CN)
- Yan'an University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2026-02-10
- DOI
- https://doi.org/10.1186/s12931-026-03560-2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00