Genomic analysis of the genetic background underlying Streptococcus pneumoniae beta-lactam nonsusceptibility in central Vietnam: increased beta-lactam nonsusceptibility and dynamics of the pbp2x gene
We revealed that the widespread nonsusceptibility to multiple beta-lactams among SP isolates circulating in central Vietnam was primarily driven by the dynamics of the pbp2x gene. However, the nonsusceptible pbp2x allele had little effect on clinical outcome.
Authors
- Daisuke Motooka (ORCID: https://orcid.org/0000-0002-4616-9608)
- Yoshitoshi Ogura (ORCID: https://orcid.org/0000-0002-4509-2653)
- Hien Anh Thi Nguyen (ORCID: https://orcid.org/0000-0002-4125-1848)
- Tetsuya Iida (ORCID: https://orcid.org/0000-0001-5134-1794)
- Đặng Đức Anh
- Kota Sasaki
- Satoshi Kakiuchi
- Lay-Myint Yoshida
- Huong Thi Lan Vu
- Mitsuhiko Sato
- Hiroshi Fujii
- Konosuke Morimoto
- Satoshi Nakano
- Shota Nakamura
- Tetsuya Hayashi
- Bhim Gopal Dhoubhadel
- Christopher M. Parry
Institutions
- Kurume University (JP)
- University of Nagasaki (JP)
- Kyushu University (JP)
- University of Oxford (GB)
- National Institute of Infectious Diseases (JP)
- National Institute Of Hygiene And Epidemiology (VN)
- Kazusa DNA Research Institute (JP)
- Nagasaki University Hospital (JP)
- Nagasaki University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Tropical Medicine and Health
- Published
- 2026-02-10
- DOI
- https://doi.org/10.1186/s41182-025-00889-0
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development