Trogocytosis-orchestrated CLDN18.2-“dressed” CD8 <sup>+</sup> T cells drive pancreatic cancer progression via glucose metabolic reprogramming-induced cytotoxicity debilitation and systematic immune senescence cascade
Trogocytosis-related CLDN18.2 inhibited the glucose uptake, glycolysis and cytotoxicity of tumour-infiltrating CD8<sup>+</sup> T cells by promoting the ubiquitin-proteasomal degradation of β-catenin in PDAC. Therefore, targeting trogocytosis-related CLDN18.2<sup>+</sup>CD8<sup>+</sup> T cells may be a promising therapeutic strategy to inhibit PDAC progression.
Authors
- Tiansuo Zhao (ORCID: https://orcid.org/0000-0003-1631-6299)
- Tinghai Hu
- Yukuan Feng (ORCID: https://orcid.org/0009-0005-6497-0748)
- Jingrui Yan
- Shangheng Shi (ORCID: https://orcid.org/0009-0006-2888-476X)
- Hongwei Wang (ORCID: https://orcid.org/0000-0001-8198-0677)
- Guohua Mao (ORCID: https://orcid.org/0000-0002-3664-1913)
- J Xu
- Tianxing Zhou (ORCID: https://orcid.org/0009-0006-0150-1343)
- Antao Chang
- Yifei Wang
- Jihui Hao
- Yaqi Zhang
- Fanyue Shao
- Song Gao
- Zekun Li
- Bin Wang
- Chongbiao Huang
- Yu Zhang
- Yongjie Xie
- Chao Yang
- Jun Yu
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
Publication Details
- Journal
- Gut
- Published
- 2026-02-10
- DOI
- https://doi.org/10.1136/gutjnl-2025-335790
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00