The perioperative microbiome of patients undergoing rectal cancer surgery: A pilot study
This pilot study reveals significant perioperative shifts in the gut microbiome of rectal cancer patients. These findings underscore the importance of considering microbiome dynamics perioperatively when designing and interpreting studies that correlate the microbiome with clinical outcomes. However, the conclusions should be viewed as preliminary and require confirmation in larger studies, including causal relation, to postoperative outcomes.
Authors
- Kevin Talboom (ORCID: https://orcid.org/0000-0002-2007-4934)
- Henry M. Wood (ORCID: https://orcid.org/0000-0003-3009-5904)
- Kiedo Wienholts (ORCID: https://orcid.org/0000-0002-3898-1663)
- Roel Hompes
- Daniel Bottomley (ORCID: https://orcid.org/0009-0000-5749-2710)
- Caroline Young (ORCID: https://orcid.org/0000-0001-5709-4413)
- Johannes H. W. de Wilt
- Joep P M Derikx
- Philip Quirke
- Claire P. M. van Helsdingen
Institutions
- University of Leeds (GB)
- Radboud University Nijmegen (NL)
- Dutch Cancer Society (NL)
- St James's University Hospital (GB)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Emma Kinderziekenhuis (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- NIHR Leeds Musculoskeletal Biomedical Research Unit (GB)
- Amsterdam University Medical Centers (NL)
- Cancer Center Amsterdam (NL)
- University of Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Colorectal Disease
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1111/codi.70397
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00