Identification of Chondrocyte Stemness-Associated Biomarkers in Osteoarthritis Using Bioinformatics and Machine Learning Approaches

Through bioinformatics analysis and IHC validation, we identified three stemness-associated biomarker genes (WWP2, CDKN1A, CRTAC1) in OA. These findings may provide meaningful implications for future clinical assessment, treatment, and research on OA.

Authors

Siyi Xie
Zhe Lv (ORCID: https://orcid.org/0000-0001-8660-7767)
Mengru Liu (ORCID: https://orcid.org/0000-0003-0856-7223)
Yongzhou Song
Tianlin Gao
Jun Ma
Ruixue Chen
Yuzhong Wang

Institutions

Hebei Medical University (CN)
Second Hospital of Hebei Medical University (CN)
Hebei Science and Technology Department (CN)

Publication Details

Journal: Journal of Inflammation Research
Published: 2026-02-01
DOI: https://doi.org/10.2147/jir.s565577
Primary Topic: Osteoarthritis Treatment and Mechanisms
Type: article
Field-Weighted Citation Impact: 0.00

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article

Identification of Chondrocyte Stemness-Associated Biomarkers in Osteoarthritis Using Bioinformatics and Machine Learning Approaches

Siyi Xie, Zhe Lv, Mengru Liu, Yongzhou Song et al.

Feb 1, 2026

Journal of Inflammation Research

Osteoarthritis Treatment and Mechanisms

article

Identification of Chondrocyte Stemness-Associated Biomarkers in Osteoarthritis Using Bioinformatics and Machine Learning Approaches

Siyi Xie, Zhe Lv, Mengru Liu, Yongzhou Song, Tianlin Gao, Jun Ma, Ruixue Chen, Yuzhong Wang

February 1, 2026article en

Abstract

Through bioinformatics analysis and IHC validation, we identified three stemness-associated biomarker genes (WWP2, CDKN1A, CRTAC1) in OA. These findings may provide meaningful implications for future clinical assessment, treatment, and research on OA.

Journal of Inflammation ResearchVol. Volume 19

Hebei Medical University (CN), Second Hospital of Hebei Medical University (CN), Hebei Science and Technology Department (CN)

Openalex Percentile: Top 63%

Osteoarthritis Treatment and Mechanisms

DOI Open Access PDF OpenAlex

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