Cross-Species Exome Sequencing Reveals Recurrent Genomic Alterations in California Sea Lion (Zalophus californianus) Urogenital Carcinoma and Highlights a Recurrent PD-L1 Variant
These results demonstrate that cross-species exome capture provides a means to identify genomic alterations that may play a role in the molecular pathogenesis of UGC in the CSL and adds to the body of evidence for an association between OtHV-1 and UGC in this species.
Authors
- Barbie Halaska
- Rachael Thomas (ORCID: https://orcid.org/0000-0002-3373-0910)
- Catherine F. Wise (ORCID: https://orcid.org/0000-0001-6294-0426)
- Isabella Livingston (ORCID: https://orcid.org/0000-0003-3951-6525)
- Pádraig J. Duignan (ORCID: https://orcid.org/0000-0002-6565-4799)
- Frances M. D. Gulland (ORCID: https://orcid.org/0000-0002-6416-0156)
- Allison N. Dickey (ORCID: https://orcid.org/0000-0002-7466-2870)
- Kathleen M. Colegrove
- Alissa C. Demming
Institutions
- Marine Mammal Center (US)
- North Carolina State University (US)
- Chicago Zoological Society (US)
- University of California, Davis (US)
Publication Details
- Journal
- Genes
- Published
- 2026-02-10
- DOI
- https://doi.org/10.3390/genes17020222
- Primary Topic
- Veterinary Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00