Effects of pentosan polysulfate sodium on joint structure and function out to six months in naturally-occurring canine osteoarthritis
PPS-treated dogs experienced improvements in pain, joint function, and cartilage volume compared to placebo, supported by changes in biomarkers at weeks 8 and 26. The 26-week timepoint in this translational canine model provides insights into the potential disease-modifying mechanisms and durability of PPS in long-term treatment outcomes in humans with OA.
Authors
- Thierry Beths (ORCID: https://orcid.org/0000-0003-1412-0591)
- Sébastien H. Bauquier (ORCID: https://orcid.org/0000-0001-7355-5590)
- Rachel A. Peat
- Catherine J. M. Stapledon
- Marjorie E. Milne
- Ravi Krishnan
- Stewart D. Ryan
- Christian Reiter
Institutions
- The University of Melbourne (AU)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-02-10
- DOI
- https://doi.org/10.1371/journal.pone.0342409
- Primary Topic
- Veterinary Orthopedics and Neurology
- Type
- article
- Field-Weighted Citation Impact
- 0.00