Genetic Variants in Genes Regulating Lens Epithelial Cell Homeostasis in Dead Bag Syndrome – Part 2

Our study highlights a set of rare genetic variants affecting genes involved in RNA processing (GEMIN4, USPL1), epithelial integrity (TJP1, MSLN), and metabolic homeostasis (APC2, CD320, TNS1, TRPM5, ZFHX3) -three key pathways crucial for LEC homeostasis. It further supports a multigenic risk model and highlights the potential use of these genes as predictive markers for DBS manifestation.

Authors

Publication Details

Journal
Journal of Cataract & Refractive Surgery
Published
2026-02-10
DOI
https://doi.org/10.1097/j.jcrs.0000000000001907
Primary Topic
Intraocular Surgery and Lenses
Type
article
Field-Weighted Citation Impact
0.00
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article

Genetic Variants in Genes Regulating Lens Epithelial Cell Homeostasis in Dead Bag Syndrome – Part 2

Shail Vasavada, Sankaranarayanan Rajkumar, Abhay R Vasavada, Vaishali Vasavada
Journal of Cataract & Refractive Surgery
Intraocular Surgery and Lenses
article

Genetic Variants in Genes Regulating Lens Epithelial Cell Homeostasis in Dead Bag Syndrome – Part 2

Shail Vasavada, Sankaranarayanan Rajkumar, Abhay R Vasavada, Vaishali Vasavada
article en

Abstract

Our study highlights a set of rare genetic variants affecting genes involved in RNA processing (GEMIN4, USPL1), epithelial integrity (TJP1, MSLN), and metabolic homeostasis (APC2, CD320, TNS1, TRPM5, ZFHX3) -three key pathways crucial for LEC homeostasis. It further supports a multigenic risk model and highlights the potential use of these genes as predictive markers for DBS manifestation.

Journal of Cataract & Refractive Surgery
Openalex Percentile: Top 60%
Intraocular Surgery and Lenses
DOISourceOpenAlex
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Genetic Variants in Genes Regulating Lens Epithelial Cell Homeostasis in Dead Bag Syndrome – Part 2 — Shail Vasavada, Sankaranarayanan Rajkumar, et al. · Journal of Cataract & Refractive Surgery (2026) | TGRS Research Map | TGRS