Hepatic stellate cell derived lipid droplets drive protumoral M2 macrophage polarization in hepatocellular carcinoma
Our findings identifies a distinct mechanism whereby activated HSCs transfer LDs to hepatic macrophages, inducing M2 polarization and creating a pro-tumorigenic microenvironment. This HSC-macrophage crosstalk represents a potential metabolic therapeutic target for preventing HCC development in patients with chronic liver disease.
Authors
- Y. Y. Wang
- Yong Ye (ORCID: https://orcid.org/0000-0002-4681-1496)
- Bin Lan (ORCID: https://orcid.org/0000-0003-3121-7643)
- Jingjie Xu
- Sha Huang (ORCID: https://orcid.org/0000-0003-2589-5181)
- Qiaoting Hu
- Qifei Li
- Zengqing Guo
- Zhouwei Zhan
Institutions
- Fujian Medical University (CN)
- Xiamen University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Fujian Provincial Cancer Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1007/s12672-026-04626-9
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00