Adjuvant PD-1 Inhibitors After Radical Surgery for High-Risk Muscle-Invasive Urothelial Carcinoma: A Systematic Review and Meta-Analysis of Phase 3 Trials

Among patients with resected high-risk MIBC, adjuvant PD-1 inhibitor therapy significantly improves DFS with an acceptable safety profile. However, owing to the limited number of studies and short follow-up periods, these findings should be considered preliminary, and longer follow-up is required to confirm any potential OS benefit.

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Publication Details

Journal
Urology Practice
Published
2026-02-10
DOI
https://doi.org/10.1097/upj.0000000000000984
Primary Topic
Bladder and Urothelial Cancer Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Adjuvant PD-1 Inhibitors After Radical Surgery for High-Risk Muscle-Invasive Urothelial Carcinoma: A Systematic Review and Meta-Analysis of Phase 3 Trials

Afef Khanfir, Wala Ben Kridis
Urology Practice
Bladder and Urothelial Cancer Treatments
article

Adjuvant PD-1 Inhibitors After Radical Surgery for High-Risk Muscle-Invasive Urothelial Carcinoma: A Systematic Review and Meta-Analysis of Phase 3 Trials

Afef Khanfir, Wala Ben Kridis
article en

Abstract

Among patients with resected high-risk MIBC, adjuvant PD-1 inhibitor therapy significantly improves DFS with an acceptable safety profile. However, owing to the limited number of studies and short follow-up periods, these findings should be considered preliminary, and longer follow-up is required to confirm any potential OS benefit.

Urology Practice
University of Sfax (TN), Hopital Universitaire Habib Bourguiba (TN)
Good health and well-being
Openalex Percentile: Top 61%
Bladder and Urothelial Cancer Treatments
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