LDLR and APOB pathogenic variants predict discordant TSH effect on LDL-C
TSH was positively associated with LDL-C only in FH due to LDLR variants, not in APOB carriers. These findings suggest that genetic background may shape hormonal sensitivity, and that attention to thyroid status could be particularly relevant in LDLR-FH.
Authors
- Matej Mlinarić
- Barbara Čugalj Kern
- Jaka Šikonja (ORCID: https://orcid.org/0000-0001-7843-8107)
- Tevž Gorjanc
- Mihaela Pricop-Jeckstadt
- J. Kafol
- Ana Drole Torkar
- Urh Groselj
- Jernej Kovac
- Andraž Petek
- Andreja Lakner
Institutions
- University of Ljubljana (SI)
- Ljubljana University Medical Centre (SI)
- Universitatea Națională de Știință și Tehnologie Politehnica București (RO)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2026-02-10
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2026.120672
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00