The effect of Wilms tumor 1-associated protein on ferroptosis and immune escape in non-small-cell lung cancer by mediating N6-methyladenosine modification of Twist1
Twist1 is highly expressed in NSCLC. It promotes NSCLC progression by enhancing ferroptosis and immune escape. WTAP-mediated m6A methylation plays a critical role in regulating Twist1 expression. The WTAP/Twist1 axis may serve as a potential therapeutic target for NSCLC.
Authors
- M Li
- Luogen Peng (ORCID: https://orcid.org/0000-0001-8181-0467)
- Xianghui Yang
- Jie Li (ORCID: https://orcid.org/0000-0002-4366-7724)
- Yueyong Li (ORCID: https://orcid.org/0000-0003-3612-9271)
- Lijuan Zou
- Li Zhao
Institutions
- Central South University (CN)
- Changsha Medical University (CN)
- Dalian Medical University (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
- Changsha Central Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- CytoJournal
- Published
- 2026-02-10
- DOI
- https://doi.org/10.25259/cytojournal_114_2025
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province