Enhanced Fluorescence of Near-Infrared Anti-CEA Antibodies for Visualizing Colorectal Cancers Using Modified Heptamethine Cyanines
Antibody-fluorophore conjugates linked to the charge-modified FNIR-Tag dyes provide improved tumor-specific signals and a more favorable biodistribution profile than the same antibody conjugated to a conventional dye. By achieving superior performance through intrinsic fluorophore design rather than complex bioconjugation strategies, the approach provides a clinically translatable advancement for tumor-specific FGS.
Authors
- Dong‐Hao Li (ORCID: https://orcid.org/0000-0003-2556-1624)
- S. Mehta
- J. Jitender
- S. Amirfakhri
- M. Bouvet
- J. Shively
- R. M. Hoffman
- T. M. Lwin
- P. Yazaki
- M. J. Schnermann
- K. Cox
Institutions
- City Of Hope National Medical Center (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- Theranostics (New Zealand) (NZ)
- National Cancer Institute (US)
- Molecular Theranostics (United States) (US)
Publication Details
- Journal
- Molecular Imaging and Biology
- Published
- 2026-02-10
- DOI
- https://doi.org/10.1007/s11307-025-02076-3
- Citations
- 1
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 21.28