Current mass spectrometry methods for the analysis of 7-ketocholesterol and related sterols

In this article we summarise the current mass spectrometry methods used for analysis of 7-ketocholesterol and related sterols, focusing on the advantages of the different methods with emphasis on pre-analytical and analytical precautions to avoid artefactual ex vivo formation of these oxysterols.

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Publication Details

Journal
The Journal of Steroid Biochemistry and Molecular Biology
Published
2026-02-10
DOI
https://doi.org/10.1016/j.jsbmb.2026.106956
Primary Topic
Cholesterol and Lipid Metabolism
Type
article
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article

Current mass spectrometry methods for the analysis of 7-ketocholesterol and related sterols

William J Griffiths, Mohsen Ali Asgari, Yuqin Wang
The Journal of Steroid Biochemistry and Molecular Biology
Cholesterol and Lipid Metabolism
article

Current mass spectrometry methods for the analysis of 7-ketocholesterol and related sterols

William J Griffiths, Mohsen Ali Asgari, Yuqin Wang
article en

Abstract

In this article we summarise the current mass spectrometry methods used for analysis of 7-ketocholesterol and related sterols, focusing on the advantages of the different methods with emphasis on pre-analytical and analytical precautions to avoid artefactual ex vivo formation of these oxysterols.

The Journal of Steroid Biochemistry and Molecular BiologyVol. 259
Swansea University (GB)
Openalex Percentile: Top 61%
Cholesterol and Lipid Metabolism
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Current mass spectrometry methods for the analysis of 7-ketocholesterol and related sterols — William J Griffiths, Mohsen Ali Asgari, et al. · The Journal of Steroid Biochemistry and Molecular Biology (2026) | TGRS Research Map | TGRS