<i>Acinetobacter baumannii</i> promotes gastric cancer metastasis via NA-mediated NAD metabolism reprogramming and glycolytic activation
This study elucidates the role of <i>A. baumannii</i> in enhancing NAD metabolism in GC cells through NA synthesis, consequently promoting GC metastasis. These findings establish a microbiota-metabolism axis as a mechanistic foundation for developing targeted therapeutic strategies against GC metastasis.
Authors
- Jun He (ORCID: https://orcid.org/0000-0002-1479-285X)
- Yong Zhang (ORCID: https://orcid.org/0000-0003-2179-3698)
- Rui Yang (ORCID: https://orcid.org/0000-0002-9679-7338)
- Jingdan Liang (ORCID: https://orcid.org/0000-0001-8984-8187)
- Jing Zhang
- Zixin Deng
- Chao He
- Yan Yang
- Haohao Wang
- Lisong Teng
Institutions
- Shanghai Jiao Tong University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Gut
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1136/gutjnl-2025-336161
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00