Effect of Xiaonang Yusi decoction (消囊育嗣汤) on IVF outcomes in patients with phlegm-dampness type PCOS: a prospective cohort study with supporting metabolomics, network pharmacology, and molecular docking analysis
Xiaonang Yusi Decoction significantly improves TCM syndrome manifestations and IVF-ET outcomes in phlegm-dampness PCOS patients, enhancing embryo quality and pregnancy rates. The therapeutic effects appear mediated through regulation of arachidonic acid metabolites, particularly 15(S)-HETE, in follicular fluid. Network pharmacology analysis has preliminarily elucidated the underlying mechanisms, providing novel evidence for TCM-based PCOS treatment strategies.
Authors
- Qingmei Jin (ORCID: https://orcid.org/0000-0003-1049-1416)
- Kailiang Ai
- Haining Yuan
- ZhenGao Sun
- Hengbing Li
- Zizhen Guo
- Ying Xu
- Xin Hu
- Zhenni Mu
- Jingyan Song
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-10
- DOI
- https://doi.org/10.3389/fmed.2026.1680327
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China