Immunometabolic transcriptomic signatures of diabetes-related genes predict kidney transplant rejection
We identified a distinct metabolic gene signature capable of predicting kidney transplant rejection. The downregulation of <i>DPP4</i> with the upregulation of <i>PPARG</i> and <i>INSR</i> suggests that metabolic reprogramming and loss of homeostasis are hallmarks of immune-mediated graft failure.
Authors
- Andrea Dello Strologo (ORCID: https://orcid.org/0000-0001-9128-6638)
- Roberto Casale (ORCID: https://orcid.org/0000-0001-7708-5303)
- Francesco Pesce
- Giuseppe Grandaliano
- Carlo Alfieri
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Université Libre de Bruxelles (BE)
- University of Milan (IT)
- Institut Jules Bordet (BE)
- Agostino Gemelli University Polyclinic (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Ospedale Maggiore (IT)
- Azienda Usl 8 Arezzo (IT)
- Izola General Hospital (SI)
Publication Details
- Journal
- Renal Failure
- Published
- 2026-02-09
- DOI
- https://doi.org/10.1080/0886022x.2026.2626857
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00