Aerobic exercise facilitates p300 nuclear translocation via ADRB2-AMPKα signaling, leading to enhanced histone acetylation and mitigation of cognitive decline in APP/PS1 mice
These findings unveil a previously unrecognized ADRB2-p-AMPKα-p300 axis that AE utilizes to orchestrate chromatin remodeling, counteracting synaptic degeneration and cognitive decline in AD, providing actionable targets for exercise-mimetic therapies.
Authors
- Fang-Zhou Wang
- Haiyan Yi
- Haitao Yu (ORCID: https://orcid.org/0009-0008-1074-5870)
- Juan Gong
- Jia-qi Yuan
- Yu-ming Mao
- Gao-shang Chai
- Liu Yang
- Shan Geng
- Ke-yu Zhang
- Shu-guang Bi
- Jia-jun Wu
- Tian-long Gao
- Jia Chen
- Zi-chong Lan
- Yun-juan Nie
Institutions
- Jiangnan University (CN)
- Wuhan Children's Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2026-02-10
- DOI
- https://doi.org/10.1186/s13195-026-01983-z
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00