Xuming tongmai decoction modulates astrocyte polarization and mitophagy via the PINK1/Parkin pathway in a rat model of acute ischemic stroke

XMTM decoction exerts its neuroprotective effects in AIS rats by targeting the PINK1/Parkin-mediated mitophagy pathway, which subsequently promotes the polarization of astrocytes toward the neuroprotective A2 phenotype.

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Publication Details

Journal
Brain Research
Published
2026-02-10
DOI
https://doi.org/10.1016/j.brainres.2026.150203
Primary Topic
Autophagy in Disease and Therapy
Type
article
Field-Weighted Citation Impact
0.00
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article

Xuming tongmai decoction modulates astrocyte polarization and mitophagy via the PINK1/Parkin pathway in a rat model of acute ischemic stroke

Xiaofang Lan, Xinyuan Yu, Rui Yang, Jun Tang et al.
Brain Research
Autophagy in Disease and Therapy
article

Xuming tongmai decoction modulates astrocyte polarization and mitophagy via the PINK1/Parkin pathway in a rat model of acute ischemic stroke

Xiaofang Lan, Xinyuan Yu, Rui Yang, Jun Tang, Zixiu Zeng, Li Ran
article en

Abstract

XMTM decoction exerts its neuroprotective effects in AIS rats by targeting the PINK1/Parkin-mediated mitophagy pathway, which subsequently promotes the polarization of astrocytes toward the neuroprotective A2 phenotype.

Brain ResearchVol. 1877-1878
First People's Hospital of Chongqing (CN)
Openalex Percentile: Top 60%
Autophagy in Disease and Therapy
DOIOpen Access PDFOpenAlex
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Xuming tongmai decoction modulates astrocyte polarization and mitophagy via the PINK1/Parkin pathway in a rat model of acute ischemic stroke — Xiaofang Lan, Xinyuan Yu, et al. · Brain Research (2026) | TGRS Research Map | TGRS