CD274 Alterations and PD-L1 Expression on Tumor Cells and Tumor-Infiltrating Lymphocytes in Patients With Melanoma: Relationships to Histopathologic Features and Outcomes
Our findings suggest that CD274 alterations, PD-L1 expression on tumor cells and TILs, BRAF mutations, genomic amplifications, and tumor mutational burden may provide meaningful prognostic information in patients with melanoma. Prospective validation in larger cohorts is warranted to confirm the utility of these markers in guiding therapeutic decisions.
Authors
- Priyadharsini Nagarajan (ORCID: https://orcid.org/0000-0002-5346-2669)
- Mahyar Khazaeli (ORCID: https://orcid.org/0000-0001-8645-4203)
- Wooram Cho
- Richard K. Yang (ORCID: https://orcid.org/0000-0003-0433-8626)
- Volha Lenskaya (ORCID: https://orcid.org/0000-0002-0852-7187)
- Michael Wong (ORCID: https://orcid.org/0000-0002-7191-0293)
- Denái R. Milton
- Aneeza Irfan (ORCID: https://orcid.org/0000-0002-7641-4029)
- Carlos A. Torres-Cabala
- Victor G. Prieto
- Phyu P. Aung
- Jonathan L. Curry
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
Publication Details
- Journal
- Archives of Pathology & Laboratory Medicine
- Published
- 2026-02-09
- DOI
- https://doi.org/10.5858/arpa.2025-0467-oa
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00