SDC1 <sup>+</sup> CAFs secreting CTGF drive tumour metastasis via FGFR3 signalling in cancers

Our study establishes SDC1<sup>+</sup> CAFs as a universal, metastasis-promoting CAF subset across multiple cancer types and uncovers a novel KLF6-CTGF-FGFR3 axis that drives EMT and tumour dissemination. These findings provide mechanistic insight into CAF-tumour cell crosstalk and highlight actionable stromal targets for anti-metastatic therapies across diverse malignancies.

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Publication Details

Journal
Gut
Published
2026-02-10
DOI
https://doi.org/10.1136/gutjnl-2025-337606
Primary Topic
Connective Tissue Growth Factor Research
Type
article
Field-Weighted Citation Impact
0.00
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article

SDC1 + CAFs secreting CTGF drive tumour metastasis via FGFR3 signalling in cancers

Yiqi Li, Jin-xin Bei, Nu Zhang, Guangzhao Lv et al.
Gut
Connective Tissue Growth Factor Research
article

SDC1 + CAFs secreting CTGF drive tumour metastasis via FGFR3 signalling in cancers

Yiqi Li, Jin-xin Bei, Nu Zhang, Guangzhao Lv, Xing-liang Tan, Peirong Ding, Jiehai Yu, Mu-Yan Cai, Weixin Liao, Shu-Wei Chen, J. R. Luo, Panpan Wei, Jian-Fu Zhao, Gong Chen, Ying Liu, Shuai He, Kai Yao, Rou Peng, Dong-Ming Kuang, Xiu-Wu Bian, Guan-Feng Gao, Zhi-Ting Sun, Jin-Li Lyu, Yu Shi, Shi-Bo Zhang, Zheng Zhao, Xin-Yuan Guan, Zhao-Hui Ruan, Yan-Jun Wang
article en

Abstract

Our study establishes SDC1<sup>+</sup> CAFs as a universal, metastasis-promoting CAF subset across multiple cancer types and uncovers a novel KLF6-CTGF-FGFR3 axis that drives EMT and tumour dissemination. These findings provide mechanistic insight into CAF-tumour cell crosstalk and highlight actionable stromal targets for anti-metastatic therapies across diverse malignancies.

Gut
Central South University (CN), Army Medical University (CN), Sun Yat-sen University (CN), Chongqing University (CN), Chinese University of Hong Kong (HK), Capital Medical University (CN), Chinese National Human Genome Center (CN), Beijing Institute of Neurosurgery (CN), Hunan Cancer Hospital (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), Southwest Hospital (CN), National Cancer Centre Singapore (SG), Sun Yat-sen University Cancer Center (CN), Nano and Advanced Materials Institute (CN), Third Xiangya Hospital (CN), First Affiliated Hospital of Jinan University (CN), University of Hong Kong (HK)
No poverty
Openalex Percentile: Top 62%
Connective Tissue Growth Factor Research
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