Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance
Lysosomes mediate BTZ resistance in GC; V8 overcomes this by disrupting lysosomes, enabling BTZ to target proteasomes. V8 + BTZ is a safe, effective strategy against GC.
Authors
- Yuhang Zhang (ORCID: https://orcid.org/0009-0007-3725-2243)
- Si-chan LI
- He Qibin
- Chuan-Yong Guo
- Yuan Gao
- Qing-Long Guo
- Shun-Zi Shao
- Wen-Tao Shang
- Yu Zhou
- Xiao-Bo Zhang
Institutions
- China Pharmaceutical University (CN)
- Shanghai Tenth People's Hospital (CN)
- Nanjing Jiangning Hospital (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2026-02-10
- DOI
- https://doi.org/10.3748/wjg.v32.i8.113299
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00