Diagnostic Utility of PRAME and SOX10 Immunostaining for Vulvar Melanocytic Lesions

SOX10 and PRAME are nuclear staining markers that can be used for diagnostic purposes and as adjunct markers for the diagnosis of VM and benign melanocytic lesions. PRAME immunostaining shows high specificity for melanoma and melanoma in situ.

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Publication Details

Journal
Cureus
Published
2026-02-09
DOI
https://doi.org/10.7759/cureus.103309
Primary Topic
Cutaneous Melanoma Detection and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Diagnostic Utility of PRAME and SOX10 Immunostaining for Vulvar Melanocytic Lesions

Vuthinun Achariyapota, Panitta Sitthinamsuwan, Kridtin Jarutatsanangkoon, Phitsinee Purngpiputtrakul
Cureus
Cutaneous Melanoma Detection and Management
article

Diagnostic Utility of PRAME and SOX10 Immunostaining for Vulvar Melanocytic Lesions

Vuthinun Achariyapota, Panitta Sitthinamsuwan, Kridtin Jarutatsanangkoon, Phitsinee Purngpiputtrakul
article en

Abstract

SOX10 and PRAME are nuclear staining markers that can be used for diagnostic purposes and as adjunct markers for the diagnosis of VM and benign melanocytic lesions. PRAME immunostaining shows high specificity for melanoma and melanoma in situ.

CureusVol. 18(2)
Siriraj Hospital (TH)
Good health and well-being
Openalex Percentile: Top 61%
Cutaneous Melanoma Detection and Management
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Diagnostic Utility of PRAME and SOX10 Immunostaining for Vulvar Melanocytic Lesions — Vuthinun Achariyapota, Panitta Sitthinamsuwan, et al. · Cureus (2026) | TGRS Research Map | TGRS