Renin–angiotensin system activation and oxidative stress in hospitalized COVID-19 patients: a single-centre prospective observational study
Worsening respiratory status in COVID-19 is associated with delayed activation of the RAS, a shift toward the alternative Ang 1-7 pathway, and parallel increases in endothelial dysfunction markers. These findings suggest that serial measurements of RAS peptides and ADMA may aid in identifying high-risk phenotypes and inform personalized therapeutic strategies in COVID-19.
Authors
- Valentina Giammatteo
- F Silvia
- Gabriele Ciasca (ORCID: https://orcid.org/0000-0002-3694-8229)
- Lavinia Santucci (ORCID: https://orcid.org/0000-0002-7448-0604)
- Rikardo Xhemalaj (ORCID: https://orcid.org/0000-0001-8957-9335)
- Aniello Primiano (ORCID: https://orcid.org/0000-0001-9415-9175)
- Salvatore Lucio Cutuli (ORCID: https://orcid.org/0000-0001-8135-6284)
- Calabrese Cesare Maria
- Andrea Urbani (ORCID: https://orcid.org/0000-0001-9168-3174)
- Riccardo Di Santo (ORCID: https://orcid.org/0000-0002-0400-4661)
- G De Pascale
- Filippo Maria Del Tedesco
- Matteo Masullo
- Davide Eleuteri
- Jacopo Gervasoni
- Simone Carelli
- Domenico Luca Grieco
- Giuseppe Bello
- Ernico Torelli
- Daniel Livanu
- the Gemelli-ICU Study Group
- Paolo De Santis
- Ersilia Ruggiero
- Valentina Di Gravio
- Antonio Gullì
- Luca Montini
- Caterina Tucciariello
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
- University of the Sacred Heart (JP)
- Link Campus University (IT)
Publication Details
- Journal
- Intensive Care Medicine Experimental
- Published
- 2026-02-10
- DOI
- https://doi.org/10.1186/s40635-026-00857-w
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00