Sevelamer inhibits the formation of cholesterol gallstones by modulating bile acid metabolism
Sev might prevent cholesterol gallstone formation by inhibiting the intestinal Fxr-Fgf15 pathway, promoting hepatic bile acid synthesis, reducing biliary cholesterol supersaturation, and restoring gut microbiota balance.
Authors
- Min Ning (ORCID: https://orcid.org/0000-0001-5236-3880)
- Qian Zhuang (ORCID: https://orcid.org/0000-0002-2108-1845)
- Zhixia Dong (ORCID: https://orcid.org/0000-0001-7474-5548)
- Shan Wu (ORCID: https://orcid.org/0000-0001-8539-3808)
- Shuang Shen (ORCID: https://orcid.org/0000-0002-0845-2533)
- Shengnan Qian
- Muhan Li
- Xin Ye
- Xinjian Wan
Institutions
- Shanghai Sixth People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-10
- DOI
- https://doi.org/10.3389/fphar.2026.1737631
- Primary Topic
- Gallbladder and Bile Duct Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- Jiangxi Normal University