Metabolomic Insights into Reprogrammed Caffeine Metabolism in the Hippocampus of Myofascial Pain Syndrome Rats

MPS causes pathological damage to the hippocampus, and increased c-fos protein expression suggests possible central sensitization in MPS rats. Metabolomics analysis revealed significant hippocampal changes, particularly reduced caffeine metabolism, underscoring potential central mechanisms in MPS. This study enhances our understanding of MPS etiology based on hippocampal pathology and provides potential biological markers.