Development and validation of UPLC-MS/MS method for pharmacokinetics and tissue distribution of Tylvalosin and its bioactive metabolites in swine
The findings confirm the optimized therapeutic potential of tylvalosin, particularly formulation I, supported by its favorable pharmacokinetic profile and tissue distribution. This study establishes a new standard for veterinary PK-PD research and provides a PK evidence-based formulation optimization approaches to enhance treatment efficacy.
Authors
- G. X. Zhang
- Xuan Luo (ORCID: https://orcid.org/0000-0002-1934-9400)
- Cong Wang
- Wenjun Hu
- Jiahui Tu
- Nini Ma
- Guangshan Zhu
- Jin Wan
- Yindi Dai
- Yuexin Dong
- Zhixia Qiu
Institutions
- China Pharmaceutical University (CN)
- National Animal Husbandry Service (CN)
Publication Details
- Journal
- Veterinary Research Communications
- Published
- 2026-02-10
- DOI
- https://doi.org/10.1007/s11259-025-11058-3
- Primary Topic
- Bioactive natural compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Pharmaceutical University
- Fundamental Research Funds for the Central Universities