Infants exposed to maternal type 1 diabetes: intrauterine epigenetic modifications and neurological development

While further confirmation is needed, we provide the first results supporting the hypothesis that neurodevelopmental alterations observed in offspring of mothers with Type-1 diabetes are potentially associated with DNA methylation changes during intrauterine life which can be identified at birth.

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Publication Details

Journal
Frontiers in Endocrinology
Published
2026-02-10
DOI
https://doi.org/10.3389/fendo.2026.1759949
Primary Topic
Gestational Diabetes Research and Management
Type
article
Field-Weighted Citation Impact
0.00

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article

Infants exposed to maternal type 1 diabetes: intrauterine epigenetic modifications and neurological development

C Flores, E. Padrón-Pérez, Adrián Muñoz-Barrera, Laura Tascón-Padrón et al.
Frontiers in Endocrinology
Gestational Diabetes Research and Management
article

Infants exposed to maternal type 1 diabetes: intrauterine epigenetic modifications and neurological development

C Flores, E. Padrón-Pérez, Adrián Muñoz-Barrera, Laura Tascón-Padrón, Candelaria González-Campos, Nazaret Villalba-Martín, Olivia Orribo-Morales, Rafaela González-Montelongo, Nieves Luisa González-González, José Ramón Castro-Conde, Marina Armas-González, Enrique González-Dávila, José Miguel Lorenzo-Salazar
article en

Abstract

While further confirmation is needed, we provide the first results supporting the hypothesis that neurodevelopmental alterations observed in offspring of mothers with Type-1 diabetes are potentially associated with DNA methylation changes during intrauterine life which can be identified at birth.

Frontiers in EndocrinologyVol. 17
Universidad de La Laguna (ES), University Hospital Bonn (DE), Hospital Universitario de Canarias (ES), Instituto de Salud Carlos III (ES), Hospital General Universitario Gregorio Marañón (ES), Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES), Instituto Tecnológico y de Energías Renovables (ES), Island Hospital (US), Universidad Europea de Canarias (ES), Fundación Canaria de Investigación Sanitaria (ES)
Instituto de Salud Carlos III, Agencia Estatal de Investigación
Good health and well-being
Openalex Percentile: Top 64%
Gestational Diabetes Research and Management
DOIOpen Access PDFOpenAlex
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Infants exposed to maternal type 1 diabetes: intrauterine epigenetic modifications and neurological development — C Flores, E. Padrón-Pérez, et al. · Frontiers in Endocrinology (2026) | TGRS Research Map | TGRS