Modulation of HMGB1-mediated neuroinflammation and synaptic plasticity by ethyl pyruvate reduces methamphetamine reward and motivation in male rats
The HMGB1 inhibitor EP attenuated METH reinforcement and motivation by targeting the IL to disrupt a neuroinflammatory cascade, prevent apoptosis and pyroptosis, and restore synaptic homeostasis. These findings identify HMGB1 inhibitors as a novel therapeutic target for mitigating the neuropathology and motivational drive underlying METH addiction.
Authors
- Xuyan Huang (ORCID: https://orcid.org/0000-0003-1626-2593)
- Huifen Liu (ORCID: https://orcid.org/0000-0003-2559-3466)
- Wenhua Zhou (ORCID: https://orcid.org/0000-0001-7128-4184)
- Yiying Zhou
- Manqing Wu
- Huizhen Liu
- Tingting Wu
- Baobao Shi
- Shanshan Chen
- Yuting Wang
- Fangmin Wang
- Miaojun Lai
- Zhongyu Zhang
Institutions
- North China University of Science and Technology (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Mental Health Center (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- Ningbo Kangning Hospital (CN)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2026-02-10
- DOI
- https://doi.org/10.1016/j.bbi.2026.106481
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00