Chicken IRF10 suppresses the cGAS-STING-IFN antiviral signaling pathway by targeting IRF7
Collectively, these findings unveil a novel immunoregulatory function of chIRF10 and delineate a previously unrecognized mechanism fine-tuning the chicken cGAS-STING-IFN antiviral pathway, offering potential insights for developing interventions against avian viral diseases.
Authors
- Hongjian Han
- Biao Sun (ORCID: https://orcid.org/0000-0001-5586-9043)
- Jingyu He (ORCID: https://orcid.org/0009-0009-9782-9897)
- Mengjia Lv
- Nanhua Chen
- Wanglong Zheng
- Jianzhong Zhu
- Sen Jiang
- Kun Wang
Institutions
- Yangzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-10
- DOI
- https://doi.org/10.3389/fimmu.2026.1767491
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Higher Education Discipline Innovation Project