Identification of potential ferroptosis-related biomarkers in proliferative vitreoretinopathy based on machine learning
This study identifies TIMP1 and STAT3 as ferroptosis-associated candidate genes in proliferative vitreoretinopathy and highlights potential links among ferroptosis-related regulatory pathways, immune microenvironment alterations, and PVR pathogenesis. These findings provide a foundation for further mechanistic studies to clarify the role of ferroptosis in PVR.
Authors
- Shengxiang Zhang (ORCID: https://orcid.org/0000-0001-6524-9673)
- Lingdan Wu (ORCID: https://orcid.org/0000-0003-3573-1455)
- Jiangying Liu (ORCID: https://orcid.org/0000-0002-6437-4330)
- Qihua Xu
- Yingchao Xue
- Boyu Liu
- Hongyan Song
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Jiangxi Provincial People's Hospital (CN)
- Jiangxi Chest Hospital (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2026-02-10
- DOI
- https://doi.org/10.3389/fmolb.2026.1725407
- Primary Topic
- Retinal and Macular Surgery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Health Commission of Jiangxi Province