Lactiplantibacillus plantarum GUANKE ameliorates influenza a virus-induced inflammation and lung barrier dysfunction through enhancing mitophagy and improving oxidative phosphorylation
Pulmonary inflammatory response represents a predominant complication arising from influenza virus infections. This investigation elucidates the protective efficacy of Lactiplantibacillus plantarum GUANKE (GUANKE) supplementation against influenza A virus (IAV)-induced pulmonary damage in C57BL/6 murine models, with particular emphasis on its mechanistic underpinnings. The results showed that the use of GUANKE (5 × 10<sup>9</sup> CFU/day) or exogenous linoleic acid (a metabolite of GUANKE) supplementation (40 mg/kg) significantly attenuated inflammatory cytokine secretion while counteracting virus-mediated downregulation of pulmonary barrier proteins. Mechanistic profiling revealed that GUANKE and GUANKE-derived linoleic acid modulates mitochondrial quality control through enhanced Parkin-dependent mitophagy coupled with restored mitochondrial oxidative phosphorylation (OXPHOS) capacity, thereby providing protection in IAV-infected mice.
Authors
- Jielan Mi
- Yuewen Yang
- Zhilin Ren (ORCID: https://orcid.org/0009-0000-4788-5019)
- Kun Yue
- Hanyu Ma
- Tao Yang
- Siqin He
- Simin Lu
- Lili Ren
- Jianguo Xu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Nankai University (CN)
- National Institute for Communicable Disease Control and Prevention (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2026-02-10
- DOI
- https://doi.org/10.1007/s00018-026-06081-9
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00