Integrative Multi-Omics Mendelian Randomization Reveals Oxidative Stress Mechanisms in Major Depressive Disorder, Bipolar Disorder, and Schizophrenia
This study provides multi-level genetic evidence supportive of a potential causal role for specific OSGs in major psychiatric disorders. We identify <i>ACE</i>, <i>ACADVL</i>, <i>IGF1R</i>, and <i>ENDOG</i> as candidate genes for further investigation, offering insights into epigenetic and transcriptional mechanisms that could inform future research on therapeutic targets.
Authors
- Nanxi Li (ORCID: https://orcid.org/0009-0007-1884-4008)
- Sihao Chen (ORCID: https://orcid.org/0000-0001-6401-9366)
- Juan Wang (ORCID: https://orcid.org/0000-0002-5023-5081)
- Tao Li
Institutions
- Allen Institute for Brain Science (US)
- Hangzhou Seventh Peoples Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Antioxidants
- Published
- 2026-02-10
- DOI
- https://doi.org/10.3390/antiox15020233
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00