The impact of vagus nerve stimulation on the most disabling seizures: A retrospective study in adults with drug-resistant epilepsy
VNS exerts a robust effect on the most disabling seizures-TCS, drop attacks, and seizure clusters-surpassing its impact on overall seizure burden. Benefits appear within the first year and persist long term. These findings support a more tailored approach to VNS candidate selection, advocating earlier use in patients with refractory, harmful seizures not eligible for curative surgery.
Authors
- Ilaria Naldi (ORCID: https://orcid.org/0000-0001-9585-6108)
- Matteo Martinoni (ORCID: https://orcid.org/0000-0002-9394-5841)
- Anna Scarabello
- Luca Zanuttini (ORCID: https://orcid.org/0009-0007-6195-1706)
- Lorenzo Ferri
- Mino Zucchelli
- F. Bisulli
- P. Tinuper
- Martino Schettino
- Antonella Boni
- Lilia Volpi
- Roberto Michelucci
- Barbara Mostacci
- Valentina Gentile
Institutions
- ASL Roma (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- Ospedale Bellaria (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Neurological Sciences
- Published
- 2026-02-10
- DOI
- https://doi.org/10.1007/s10072-026-08868-x
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00